Virus causing Inclusion Body Disease related to Ebola

Even a hint of Inclusion Body Disease (IBD) makes the skin of any boid keeper crawl. It is a certain death for not only the diagnosed snake but the rest of the animals in your home, because of the inability to properly diagnose and treat the condition. But thanks to Larry, a boa constrictor, that may change.

When a California woman named Taryn Hook brought Larry — all 7 feet (2 meters) of him — to the vet a few years ago, she never imagined that the trip would one day lead to such a remarkable discovery, which was announced today (Aug. 14) in the journal mBio. IBD afflicts pythons and boa constrictors, causing a host of strange symptoms. The snakes tie themselves in knots, they projectile vomit and engage in an eerie behavior called stargazing; the snakes raise their heads over and over, stare into thin air, and sway drunkenly from side to side. Biopsies from animals with the disease show their cells filled up with globules of proteins called inclusions, which may be responsible for the odd behaviors. There's no cure for the disease. It moves swiftly in pythons, and can progress slowly in boa constrictors, but it is always fatal. And it's infectious, moving from snake to snake, though the mechanism of transmission isn't entirely clear. If one animal in a collection gets IBD, typically all the animals are euthanized. Blood tests had suggested Larry, a Dumeril's boa constrictor, might have IBD. Wanting to know what could be done to save the beloved snake, Hook contacted Joseph DeRisi at the University of California, San Francisco, a virologist known for his work deciphering another mysterious virus, this one affecting macaws and parrots. Her plea for help led DeRisi's lab to take on IBD. The scientists put out a call for samples of diseased and nondiseased snakes. Perhaps luckily, the Steinhart Aquarium at the California Academy of Sciences, just a few miles away, had a sudden outbreak of IBD.

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