1. Nouira, S., et al., Right ventricular dysfunction following severe

scorpion envenomation. Chest, 1995. 108(3): p. 682-7. 2. Abroug, F., et al.,

Assessment of left ventricular function in severe scorpion envenomation:

combined hemodynamic and echo-Doppler study. Intensive-Care-Med, 1995.

21(8): p. 629-35. 3. Krifi, M.N., A.-M. el, and K. Dellagi, New procedures

and parameters for better evaluation of Androctonus australis garzonii (Aag)

and Buthus occitanus tunetanus (Bot) scorpion envenomations and specific

serotherapy treatment. Toxicon, 1996. 34(2): p. 257-66. 4. Darbon, H., C.

Weber, and W. Braun, Two-dimensional 1H nuclear magnetic resonance study of

AaH IT, an anti-insect toxin from the scorpion Androctonus australis Hector.

Sequential resonance assignments and folding of the polypeptide chain.

Biochemistry, 1991. 30(7): p. 1836-45. 5. Kharrat, R., et al.,

Structure/activity relationships of scorpion alpha-toxins. Multiple residues

contribute to the interaction with receptors. Eur-J-Biochem, 1989. 181(2):

p. 381-90. 6. Martin, M.F. and H. Rochat, Purification and amino acid

sequence of toxin I" from the venom of the North African scorpion

Androctonus australis Hector. . 7. Devaux, C., et al., Fine molecular

analysis of the antigenicity of the Androctonus australis hector scorpion

neurotoxin II: a new antigenic epitope disclosed by the Pepscan method.

Mol-Immunol, 1993. 30(12): p. 1061-8. 8. Sampieri, F., et al., Amino acid

sequence of toxin XI of the scorpion Buthus occitanus tunetanus. Evidence of

a mutation having an important effect upon neurotoxic activity.

Int-J-Pept-Protein-Res, 1987. 29(2): p. 231-7. 9. Kharrat, R., et al.,

Structure-activity relationships of scorpion alpha-neurotoxins: contribution

of arginine residues. . 10. Mansuelle, P., et al., The amino acid sequence

of toxin IV from the Androctonus australis scorpion: differing effects of

natural mutations in scorpion alpha-toxins on their antigenic and toxic

properties. . 11. Higgs, S., et al., Mosquito sensitivity to a scorpion

neurotoxin expressed using an infectious Sindbis virus vector.

Insect-Mol-Biol, 1995. 4(2): p. 97-103. 12. Loret, E.P., et al.,

Conformational flexibility of a scorpion toxin active on mammals and

insects: a circular dichroism study. . 13. Loret, E.P., et al., An

anti-insect toxin purified from the scorpion Androctonus australis Hector

also acts on the alpha- and beta-sites of the mammalian sodium channel:

sequence and circular dichroism study. Biochemistry, 1991. 30(3): p. 633-40.

14. Ismail, M., E.-M.A. Abd, and A.-M.S. al, Androctonus crassicauda

(Olivier), a dangerous and unduly neglected scorpion--I. Pharmacological and

clinical studies. Toxicon, 1994. 32(12): p. 1599-618. 15. Radmanesh, M.,

Androctonus crassicauda sting and its clinical study in Iran.

J-Trop-Med-Hyg, 1990. 93(5): p. 323-6. 16. Crest, M., et al., Kaliotoxin, a

novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels

characterized from Androctonus mauretanicus mauretanicus venom. J-Biol-Chem,

1992. 267(3): p. 1640-7. 17. Fern'andez, I., et al., Kaliotoxin (1-37) shows

structural differences with related potassium channel blockers.

Biochemistry, 1994. 33(47): p. 14256-63. 18. Blanc, E., et al., Solution

structure of P01, a natural scorpion peptide structurally analogous to

scorpion toxins specific for apamin- sensitive potassium channel. Proteins,

1996. 24(3): p. 359-69. 19. Meunier, S., et al., Solution structure of

P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive

potassium channel. Biochemistry, 1993. 32(45): p. 11969-76. 20. Sabatier,

J.M., et al., P05, a new leiurotoxin I-like scorpion toxin: synthesis and

structure-activity relationships of the alpha-amidated analog, a ligand of

Ca(2+)-activated K+ channels with increased affinity. Biochemistry, 1993.

32(11): p. 2763-70. 21. Zerrouk, H., et al., Characterization of a new

leiurotoxin I-like scorpion toxin. PO5 from Androctonus mauretanicus

mauretanicus. FEBS-Lett, 1993. 320(3): p. 189-92. 22. Ji, Y.H., et al.,

Amino acid sequence of an excitatory insect-selective toxin (BmK IT) from

venom of the scorpion Buthus martensi Karsch. Sci-China--B, 1994. 37(1): p.

42-9. 23. Ji, Y.H., et al., Molecular characteristics of four new depressant

insect neurotoxins purified from venom of Buthus martensi Karsch by HPLC.

Sci-China--B, 1994. 37(8): p. 955-63. 24. Gong, J.P., M.C. Gwee, and P.

Gopalakrishnakone, Buthus martensi karsch venom: prejunctional adrenergic

activity in the rat isolated anococcygeus muscle. Toxicon, 1995. 33(9): p.

1133-9. 25. Vargas, O., M.F. Martin, and H. Rochat, Characterization of six

toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei.

Eur-J-Biochem, 1987. 162(3): p. 589-99. 26. Bouhaouala, Z.-B., et al., A

recombinant insect-specific alpha-toxin of Buthus occitanus tunetanus

scorpion confers protection against homologous mammal toxins. Eur-J-Biochem,

1996. 238(3): p. 653-60. 27. Cook, R., Insiduous effects of the Indian Red

scorpion, . 1996. 28. Santhanakrishnan, B.R. and B.S. Gajalakshmi,

Pathogenesis of cardiovascular complications in children following scorpion

envenoming. Ann-Trop-Paediatr, 1986. 6(2): p. 117-21. 29. Bawaskar, H.S. and

P.H. Bawaskar, Vasodilators: scorpion envenoming and the heart (an Indian

experience). Toxicon, 1994. 32(9): p. 1031-40. 30. Rowan, E.G., et al., The

effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro.

Toxicon, 1992. 30(10): p. 1157-64. 31. Gwee, M.C., et al., Prejunctional

action of the venom from the Indian red scorpion Mesobuthus tamulus on

adrenergic transmission in vitro. Toxicon, 1994. 32(2): p. 201-9. 32. Kari,

R.K. and H. Zolfaghrian, Increased osmotic fragility of red cells in dogs

with acute myocarditis produced by scorpion (Buthus tamulus) venom.

Indian-J-Physiol-Pharmacol, 1986. 30(3): p. 215-22. 33. Flinn, J.P., et al.,

Synthesis and biological characterisation of a series of iberiotoxin

analogues. Int-J-Pept-Protein-Res, 1995. 45(4): p. 320-5. 34. Candia, S.,

M.L. Garcia, and R. Latorre, Mode of action of iberiotoxin, a potent blocker

of the large conductance Ca(2+)-activated K+ channel. Biophys-J, 1992.

63(2): p. 583-90. 35. Giangiacomo, K.M., M.L. Garcia, and O.B. McManus,

Mechanism of iberiotoxin block of the large-conductance calcium-activated

potassium channel from bovine aortic smooth muscle. Biochemistry, 1992.

31(29): p. 6719-27. 36. Galvez, A., et al., Purification and

characterization of a unique, potent, peptidyl probe for the high

conductance calcium-activated potassium channel from venom of the scorpion

Buthus tamulus. J-Biol-Chem, 1990. 265(19): p. 11083-90. 37. Bond, G.R.,

Antivenin administration for Centruroides scorpion sting: risks and

benefits. Ann-Emerg-Med, 1992. 21(7): p. 788-91. 38. Zamudio, F., et al.,

Amino acid sequence and immunological characterization with monoclonal

antibodies of two toxins from the venom of the scorpion Centruroides noxius

Hoffmann. Eur-J-Biochem, 1992. 204(1): p. 281-92. 39. Dehesa, D.a.-M., et

al., Isolation of a toxin from Centruroides infamatus infamatus Koch

scorpion venom that modifies Na+ permeability on chick dorsal root ganglion

cells. Toxicon, 1994. 32(12): p. 1487-93. 40. Dehesa, D.a.-M., et al.,

Structural and functional comparison of toxins from the venom of the

scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus

and Centruroides noxius. Comp-Biochem-Physiol-B-Biochem-Mol-Biol, 1996.

113(2): p. 331-9. 41. Lebreton, F., et al., Primary and NMR

three-dimensional structure determination of a novel crustacean toxin from

the venom of the scorpion Centruroides limpidus limpidus Karsch.

Biochemistry, 1994. 33(37): p. 11135-49. 42. Ram'irez, A.N., et al.,

Isolation and characterization of a novel toxin from the venom of the

scorpion Centruroides limpidus limpidus Karsch. Toxicon, 1994. 32(4): p.

479-90. 43. Martin, B.M., et al., Novel K(+)-channel-blocking toxins from

the venom of the scorpion Centruroides limpidus limpidus Karsch. Biochem-J,

1994. 304(Pt 1): p. 51-6. 44. Garcia, C.-M., et al., Purification,

characterization, and biosynthesis of margatoxin, a component of

Centruroides margaritatus venom that selectively inhibits voltage-dependent

potassium channels. J-Biol-Chem, 1993. 268(25): p. 18866-74. 45. Bednarek,

M.A., et al., Chemical synthesis and structure-function studies of

margatoxin, a potent inhibitor of voltage-dependent potassium channel in

human T lymphocytes. Biochem-Biophys-Res-Commun, 1994. 198(2): p. 619-25.

46. Lin, C.S., et al., Voltage-gated potassium channels regulate

calcium-dependent pathways involved in human T lymphocyte activation.

J-Exp-Med, 1993. 177(3): p. 637-45. 47. Aiyar, J., et al., Topology of the

pore-region of a K+ channel revealed by the NMR-derived structures of

scorpion toxins. Neuron, 1995. 15(5): p. 1169-81. 48. Bablito, J., E. Jover,

and F. Couraud, Activation of the voltage-sensitive sodium channel by a

beta- scorpion toxin in rat brain nerve-ending particles. J-Neurochem, 1986.

46(6): p. 1763-70. 49. G'Asp'ar, R., Jr., et al., Beta-scorpion toxin 2 from

Centruroides noxius blocks voltage- gated K+ channels in human lymphocytes.

Biochem-Biophys-Res-Commun, 1995. 213(2): p. 419-23. 50. Gurrola, G.B., et

al., Synthetic peptides corresponding to the sequence of noxiustoxin

indicate that the active site of this K+ channel blocker is located on its

amino-terminal portion. . 51. Harvey, A.L., D.L. Marshall, and L.D. Possani,

Dendrotoxin-like effects of noxiustoxin. Toxicon, 1992. 30(11): p. 1497-500.

52. Sacile, R., et al., Secondary structure of noxiustoxin and charybdotoxin

from hydropathy power spectra. Biochem-Biophys-Res-Commun, 1994. 201(1): p.

186-93. 53. Valdivia, H.H., et al., Noxiustoxin and leiurutoxin III, two

homologous peptide toxins with binding properties to synaptosomal membrane

K+ channels. Biochem-Int, 1992. 27(6): p. 953-62. 54. Curry, S.C., et al.,

Envenomation by the scorpion Centruroides sculpturatus. . 55. Rimsza, M.E.,

D.R. Zimmerman, and P.S. Bergeson, Scorpion envenomation. Pediatrics, 1980.

66(2): p. 298-302. 56. Gateau, T., M. Bloom, and R. Clark, Response to

specific Centruroides sculpturatus antivenom in 151 cases of scorpion

stings. . 57. Grange, R.G., Elevation of blood pressure and plasma renin

levels by venom from scorpions, Centruroides sculpturatus and Leiurius

quinquestriatus. . 58. Clark, R.F., et al., Abnormal eye movements

encountered following severe envenomations by Centruroides sculpturatus.

Neurology, 1991. 41(4): p. 604. 59. Pete, M.J., J.M. Conlon, and R.F.

Murphy, Isolation and primary structure of a potent toxin from the venom of

the scorpion Centruroides sculpturatus Ewing. Int-J-Pept-Protein-Res, 1992.

40(6): p. 582-6. 60. Jablonsky, M.J., D.D. Watt, and N.R. Krishna, Solution

structure of an Old World-like neurotoxin from the venom of the New World

scorpion Centruroides sculpturatus Ewing. J-Mol-Biol, 1995. 248(2): p.

449-58. 61. el, A.-M., et al., Differential effects of defined chemical

modifications on antigenic and pharmacological activities of scorpion alpha

and beta toxins. Eur-J-Biochem, 1986. 155(2): p. 289-94. 62. Jaimovich, E.,

et al., Centruroides toxin, a selective blocker of surface Na+ channels in

skeletal muscle: voltage-clamp analysis and biochemical characterization of

the receptor. Proc-Natl-Acad-Sci-U-S-A, 1982. 79(12): p. 3896-900. 63.

Torregiani, F. and C.-C. La, [Scorpion sting (Euscorpius, sp.) in Italy and

review of scorpionism]. Minerva-Med, 1990. 81(7-8 Suppl): p. 137-45. 64.

Dasgupta, S.C., et al., Isolation, purification and immunological evaluation

of toxin Hb from scorpion Heterometrus bengalensis (C.L. Koch) venom.

Indian-J-Exp-Biol, 1990. 28(2): p. 144-8. 65. Gwee, M.C., et al., The black

scorpion Heterometrus longimanus: pharmacological and biochemical

investigation of the venom. Toxicon, 1993. 31(10): p. 1305-14. 66. Narayana,

R.-B.S., B.-L. Maniraj, and K.S. Babu, Impact of scorpion Heterometrus

fulvipes venom on cholinesterase rhythmicity in the tropical mouse Mus

booduga. Indian-J-Physiol-Pharmacol, 1984. 28(1): p. 47-52. 67. Ramanaiah,

M. and B. Venkaiah, Characterization of superoxide dismutase from south

Indian scorpion venom. Biochem-Int, 1992. 26(1): p. 113-23. 68. Sofer, S.

and M. Gueron, Respiratory failure in children following envenomation by the

scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects. .

69. Ismail, M., A.J. Fatani, and T.T. Dabees, Experimental treatment

protocols for scorpion envenomation: a review of common therapies and an

effect of kallikrein-kinin inhibitors [see comments]. Toxicon, 1992. 30(10):

p. 1257-79. 70. Garcia, M.L., et al., Purification and characterization of

three inhibitors of voltage-dependent K+ channels from Leiurus

quinquestriatus var. hebraeus venom. Biochemistry, 1994. 33(22): p. 6834-9.

71. Krezel, A.M., et al., Solution structure of the potassium channel

inhibitor agitoxin 2: caliper for probing channel geometry. Protein-Sci,

1995. 4(8): p. 1478-89. 72. Schweitz, H., et al., Charybdotoxin is a new

member of the K+ channel toxin family that includes dendrotoxin I and mast

cell degranulating peptide. Biochemistry, 1989. 28(25): p. 9708-14. 73.

Schweitz, H., et al., Charybdotoxin blocks dendrotoxin-sensitive

voltage-activated K+ channels. FEBS-Lett, 1989. 250(2): p. 519-22. 74.

DeBin, J.A., J.E. Maggio, and G.R. Strichartz, Purification and

characterization of chlorotoxin, a chloride channel ligand from the venom of

the scorpion. Am-J-Physiol, 1993. 264(2 Pt 1): p. C361-9. 75. Lippens, G.,

et al., NMR sequential assignments and solution structure of chlorotoxin, a

small scorpion toxin that blocks chloride channels. Biochemistry, 1995.

34(1): p. 13-21. 76. Martins, J.C., d.-V.-.F.J. Van, and F.A. Borremans,

Determination of the three-dimensional solution structure of scyllatoxin by

1H nuclear magnetic resonance. J-Mol-Biol, 1995. 253(4): p. 590-603. 77.

Ismail, M., A.-M.F. el, and O.H. Osman, Pharmacological studies with

scorpion (Palamneus gravimanus) venom: evidence for the presence of

histamine. Toxicon, 1975. 13(1): p. 49-56. 78. Pappone, P.A. and M.D.

Cahalan, Pandinus imperator scorpion venom blocks voltage-gated potassium

channels in nerve fibers. J-Neurosci, 1987. 7(10): p. 3300-5. 79. Sands,

S.B., R.S. Lewis, and M.D. Cahalan, Charybdotoxin blocks voltage-gated K+

channels in human and murine T lymphocytes. J-Gen-Physiol, 1989. 93(6): p.

1061-74. 80. Pappone, P.A. and M.T. Lucero, Pandinus imperator scorpion

venom blocks voltage-gated potassium channels in GH3 cells. J-Gen-Physiol,

1988. 91(6): p. 817-33. 81. Valdivia, H.H., et al., Scorpion toxins targeted

against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and

cardiac muscle. Proc-Natl-Acad-Sci-U-S-A, 1992. 89(24): p. 12185-9. 82. el,

H.-R., et al., Peptide probe of ryanodine receptor function. Imperatoxin A,

a peptide from the venom of the scorpion Pandinus imperator, selectively

activates skeletal-type ryanodine receptor isoforms. J-Biol-Chem, 1995.

270(48): p. 28696-704. 83. Olamendi, P.-T., et al., A novel structural class

of K+-channel blocking toxin from the scorpion Pandinus imperator.

Biochem-J, 1996. 315(Pt 3): p. 977-81. 84. Saunders, C.R. and A.B. Morar,

Beware the scorpion parabuthus [letter]. Cent-Afr-J-Med, 1990. 36(4): p.

114-5. 85. Muller, G.J., Scorpionism in South Africa. A report of 42 serious

scorpion envenomations. S-Afr-Med-J, 1993. 83(6): p. 405-11. 86. Bucaretchi,

F., et al., A comparative study of severe scorpion envenomation in children

caused by Tityus bahiensis and Tityus serrulatus.

Rev-Inst-Med-Trop-Sao-Paulo, 1995. 37(4): p. 331-6. 87. Becerril, B., et

al., Toxic peptides and genes encoding toxin gamma of the Brazilian

scorpions Tityus bahiensis and Tityus stigmurus. Biochem-J, 1996. 313(Pt 3):

p. 753-60. 88. Trequattrini, C., et al., Tityus bahiensis toxin IV-5b

selectively affects Na channel inactivation in chick dorsal root ganglion

neurons. Comp-Biochem-Physiol-A-Physiol, 1995. 112(1): p. 21-8. 89. Gueron,

M., R. Ilia, and S. Sofer, The cardiovascular system after scorpion

envenomation. A review. . 90. Cupo, P., et al., Severe scorpion envenomation

in Brazil. Clinical, laboratory and anatomopathological aspects.

Rev-Inst-Med-Trop-Sao-Paulo, 1994. 36(1): p. 67-76. 91. Amaral, C.F., et

al., Scorpion sting-induced pulmonary oedema: evidence of increased

alveolocapillary membrane permeability. Toxicon, 1994. 32(8): p. 999-1003.

92. Marangoni, S., et al., The complete amino acid sequence of toxin TsTX-VI

isolated from the venom of the scorpion Tityus serrulatus. J-Protein-Chem,

1990. 9(5): p. 595-601. 93. Couto, A.S., et al., Effects of toxin Ts-gamma,

purified from Tityus serrulatus scorpion venom, on the isolated rat atria.

Toxicon, 1992. 30(3): p. 339-43. 94. Yatani, A., et al., Effects of New

World scorpion toxins on single-channel and whole cell cardiac sodium

currents. Am-J-Physiol, 1988. 254(3 Pt 2): p. H443-51. 95. Lima, E.G., et

al., Acute pulmonary edema induced by injections of tityustoxin into the

lateral ventricles of rats. Toxicon, 1975. 13(3): p. 205-6. 96. Henriques,

M.C. and M.V. Gomez, The effect of scorpion venom tityustoxin on the uptake

of calcium in synaptosomes. Brain-Res-Bull, 1981. 7(3): p. 255-9. 97.

Marangoni, S., et al., Amino acid sequence of TsTX-V, an alpha-toxin from

Tityus serrulatus scorpion venom, and its effect on K+ permeability of

beta-cells from isolated rat islets of Langerhans. Biochim-Biophys-Acta,

1995. 1243(3): p. 309-14. 98. De, L.-M.E., et al., Tityus serrulatus toxin

VII bears pharmacological properties of both beta-toxin and insect toxin

from scorpion venoms. Biochem-Biophys-Res-Commun, 1986. 139(1): p. 296-302.

99. Eccles, C.U., et al., Tityustoxin-K alpha, from scorpion venom, blocks

voltage-gated, non-inactivating potassium current in cultured central

neurons. Neuropharmacology, 1994. 33(12): p. 1523-8. 100. Olivera, B.M., et

al., Peptide neurotoxins from fish-hunting cone snails. Science, 1985.

230(4732): p. 1338-43. 101. Adams, M.E., E.E. Herold, and V.J. Venema, Two

classes of channel-specific toxins from funnel web spider venom.

J-Comp-Physiol-A, 1989. 164(3): p. 333-42. 102. Cordeiro, M.d.-N., et al.,

Purification and amino acid sequences of six Tx3 type neurotoxins from the

venom of the Brazilian 'armed' spider Phoneutria nigriventer (Keys).

Toxicon, 1993. 31(1): p. 35-42. 103. Pocock, J.M. and D.G. Nicholls, A toxin

(Aga-GI) from the venom of the spider Agelenopsis aperta inhibits the

mammalian presynaptic Ca2+ channel coupled to glutamate exocytosis.

Eur-J-Pharmacol, 1992. 226(4): p. 343-50. 104. Jackson, H. and T.N. Parks,

Anticonvulsant action of an arylamine-containing fraction from Agelenopsis

spider venom. Brain-Res, 1990. 526(2): p. 338-41. 105. Kiskin, N.I., et al.,

A highly potent and selective N-methyl-D-aspartate receptor antagonist from

the venom of the Agelenopsis aperta spider. Neuroscience, 1992. 51(1): p.

11-8. 106. Parks, T.N., et al., Arylamine toxins from funnel-web spider

(Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function

in mammalian brain. J-Biol-Chem, 1991. 266(32): p. 21523-9. 107. Williams,

K., Effects of Agelenopsis aperta toxins on the N-methyl-D- aspartate

receptor: polyamine-like and high-affinity antagonist actions.

J-Pharmacol-Exp-Ther, 1993. 266(1): p. 231-6. 108. Skinner, W.S., et al.,

Purification and characterization of two classes of neurotoxins from the

funnel web spider, Agelenopsis aperta. J-Biol-Chem, 1989. 264(4): p. 2150-5.

109. Omecinsky, D.O., et al., Three-dimensional structure analysis of

mu-agatoxins: further evidence for common motifs among neurotoxins with

diverse ion channel specificities. Biochemistry, 1996. 35(9): p. 2836-44.

110. Liang, S.P., et al., Properties and amino acid sequence of

huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird

spider Selenocosmia huwena. Toxicon, 1993. 31(8): p. 969-78. 111. Adams,

M.E., et al., Omega-agatoxins: novel calcium channel antagonists of two

subtypes from funnel web spider (Agelenopsis aperta) venom. J-Biol-Chem,

1990. 265(2): p. 861-7. 112. Bindokas, V.P. and M.E. Adams, omega-Aga-I: a

presynaptic calcium channel antagonist from venom of the funnel web spider,

Agelenopsis aperta. J-Neurobiol, 1989. 20(4): p. 171-88. 113. Troncone,

L.R., et al., Biochemical and pharmacological studies on a lethal neurotoxic

polypeptide from Phoneutria nigriventer spider venom. Neurochem-Res, 1995.

20(7): p. 879-83. 114. Adams, M.E., et al., Toxityping rat brain calcium

channels with omega-toxins from spider and cone snail venoms. Biochemistry,

1993. 32(47): p. 12566-70. 115. Reily, M.D., V. Thanabal, and M.E. Adams,

The solution structure of omega-Aga-IVB, a P-type calcium channel antagonist

from venom of the funnel web spider, Agelenopsis aperta. J-Biomol-NMR, 1995.

5(2): p. 122-32. 116. Sheumack, D.D., et al., Protection of monkeys against

the lethal effects of male funnel-web spider (Atrax robustus) venom by

immunization with a toxoid. . 117. Atkinson, R.K., Some studies of the

oedematogenic action of the venom of funnel-web spiders (Atrax species).

Aust-J-Exp-Biol-Med-Sci, 1986. 64(Pt 5): p. 453-64. 118. Harris, J.B., S.

Sutherland, and M.A. Zar, Actions of the crude venom of the Sydney

funnel-web spider. Atrax robustus on autonomic neuromuscular transmission.

Br-J-Pharmacol, 1981. 72(2): p. 335-40. 119. Mylecharane, E.J., I. Spence,

and R.P. Gregson, In vivo actions of atraxin, a protein neurotoxin from the

venom glands of the funnel-web spider (Atrax robustus). . 120. Sheumack,

D.D., et al., Complete amino acid sequence of a new type of lethal

neurotoxin from the venom of the funnel-web spider Atrax robustus.

FEBS-Lett, 1985. 181(1): p. 154-6. 121. Brown, M.R., et al., Amino acid

sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web

spider Atrax versutus [published erratum appears in Biochem J 1989 Feb

1;257(3):following 934]. Biochem-J, 1988. 250(2): p. 401-5. 122. Chieng, B.,

M.E. Howden, and M.J. Christie, Australian funnel-web spider toxin,

versutoxin, enhances spontaneous synaptic activity in single brain neurons

in vitro. Brain-Res, 1993. 626(1-2): p. 136-42. 123. Newlands, G. and P.

Atkinson, Review of southern African spiders of medical importance, with

notes on the signs and symptoms of envenomation. S-Afr-Med-J, 1988. 73(4):

p. 235-9. 124. Newlands, G. and P. Atkinson, Behavioural and epidemiological

considerations pertaining to necrotic araneism in southern Africa.

S-Afr-Med-J, 1990. 77(2): p. 92-5. 125. Krinsky, W.L., Envenomation by the

sac spider Chiracanthium mildei. Cutis, 1987. 40(2): p. 127-9. 126.

Meinwald, J. and T. Eisner, The chemistry of phyletic dominance.

Proc-Natl-Acad-Sci-U-S-A, 1995. 92(1): p. 14-8. 127. Bowers, C.W., et al.,

Identification and purification of an irreversible presynaptic neurotoxin

from the venom of the spider Hololena curta. Proc-Natl-Acad-Sci-U-S-A, 1987.

84(10): p. 3506-10. 128. Lundy, P.M. and R. Frew, Pharmacological

characterization of voltage-sensitive Ca2+ channels in autonomic nerves.

Eur-J-Pharmacol, 1993. 231(2): p. 197-202. 129. Lundy, P.M., A. Hong, and R.

Frew, Inhibition of a dihydropyridine, omega-conotoxin insensitive Ca2+

channel in rat synaptosomes by venom of the spider Hololena curta.

Eur-J-Pharmacol, 1992. 225(1): p. 51-6. 130. Rauber, A., Black widow spider

bites. . 131. Mareti'c, Z., Latrodectism: variations in clinical

manifestations provoked by Latrodectus species of spiders. . 132. Muller,

G.J., Black and brown widow spider bites in South Africa. A series of 45

cases. S-Afr-Med-J, 1993. 83(6): p. 399-405. 133. Ramialiharisoa, A., et

al., [Latrodectism in Madagascar]. . 134. Byrne, G.C. and P.J. Pemberton,

Red-back spider (Latrodectus mactans hasselti) envenomation in a neonate.

Med-J-Aust, 1983. 2(12): p. 665-6. 135. Brown, A.F., Delayed diagnosis of

red-back spider envenomation: a timely reminder. Med-J-Aust, 1989.

151(11-12): p. 705-6. 136. Kleiner, B.-A., [Black widow spider bite in the

Negev]. Harefuah, 1991. 120(5): p. 257-60. 137. Visser, L.H. and S.N. Khusi,

Pulmonary oedema from a widow spider bite. A case report. S-Afr-Med-J, 1989.

75(7): p. 338-9. 138. Moss, H.S. and L.S. Binder, A retrospective review of

black widow spider envenomation. Ann-Emerg-Med, 1987. 16(2): p. 188-92. 139.

Wilson, D.C. and L.E. King, Jr., Spiders and spider bites. Dermatol-Clin,

1990. 8(2): p. 277-86. 140. Binder, L.S., Acute arthropod envenomation.

Incidence, clinical features and management. Med-Toxicol-Adverse-Drug-Exp,

1989. 4(3): p. 163-73. 141. Watanabe, O. and J. Meldolesi, The effects of

alpha-latrotoxin of black widow spider venom on synaptosome ultrastructure.

A morphometric analysis correlating its effects on transmitter release.

J-Neurocytol, 1983. 12(3): p. 517-31. 142. Linial, M., N. Ilouz, and N.

Feinstein, alpha-latrotoxin is a potent inducer of neurotransmitter release

in Torpedo electric organ--functional and morphological characterization.

Eur-J-Neurosci, 1995. 7(4): p. 742-52. 143. Scheer, H.W., Interactions

between the presynaptically active neurotoxins alpha-latrotoxin and

omega-conotoxin GVIA: studies on calcium fluxes and binding parameters in

rat and chicken synaptosomes. Can-J-Physiol-Pharmacol, 1990. 68(8): p.

1049-54. 144. D'Iez, G.i.-F., et al., [Black widow spider (Latrodectus

tredecimguttatus) bite. Presentation of 12 cases]. Med-Clin-Barc, 1996.

106(9): p. 344-6. 145. Queiroz, L.S. and L.W. Duchen, Effects of Latrodectus

spider venoms on sensory and motor nerve terminals of muscle spindles.

Proc-R-Soc-Lond-B-Biol-Sci, 1982. 216(1202): p. 103- 10. 146. Pescatori, M.,

et al., The cloning of a cDNA encoding a protein (latrodectin) which

co-purifies with the alpha-latrotoxin from the black widow spider

Latrodectus tredecimguttatus (Theridiidae). Eur-J-Biochem, 1995. 230(1): p.

322-8. 147. Petrenko, A.G., et al., [Study of the receptor for black widow

spider neurotoxin. I. Characteristics of membrane-bound and solubilized

receptors from the bovine brain]. Bioorg-Khim, 1990. 16(2): p. 149-57. 148.

Gendron, B.P., Loxosceles reclusa envenomation [see comments].

Am-J-Emerg-Med, 1990. 8(1): p. 51-4. 149. Gross, A.S., D.C. Wilson, and L.E.

King, Jr., Persistent segmental cutaneous anesthesia after a brown recluse

spider bite. South-Med-J, 1990. 83(11): p. 1321-3. 150. Wasserman, G.S. and

P.C. Anderson, Loxoscelism and necrotic arachnidism. . 151. Patel, K.D., et

al., The necrotic venom of the brown recluse spider induces dysregulated

endothelial cell-dependent neutrophil activation. Differential induction of

GM-CSF, IL-8, and E-selectin expression. J-Clin-Invest, 1994. 94(2): p.

631-42. 152. Futrell, J.M. and P.N. Morgan, Inhibition of human complement

components by Loxosceles reclusa venom. . 153. Bernheimer, A.W., B.J.

Campbell, and L.J. Forrester, Comparative toxinology of Loxosceles reclusa

and Corynebacterium pseudotuberculosis. Science, 1985. 228(4699): p. 590-1.

154. Rees, R.S., et al., Interaction of brown recluse spider venom on cell

membranes: the inciting mechanism? J-Invest-Dermatol, 1984. 83(4): p. 270-5.

155. Kurpiewski, G., et al., Platelet aggregation and sphingomyelinase D

activity of a purified toxin from the venom of Loxosceles reclusa.

Biochim-Biophys-Acta, 1981. 678(3): p. 467-76. 156. Futrell, J.M., et al.,

Location of brown recluse venom attachment sites on human erythrocytes by

the firritin-labeled antibody technique. Am-J-Pathol, 1979. 95(3): p.

675-82. 157. Schenone, H., et al., [Loxoscelism in Chile. Epidemiologic,

clinical and experimental studies]. Rev-Inst-Med-Trop-Sao-Paulo, 1989.

31(6): p. 403-15. 158. Bravo, M., et al., [Hemolysis induced by Loxosceles

laeta venom. In vitro experience]. Rev-Med-Chil, 1993. 121(1): p. 16-20.

159. Campbell, D.S., R.S. Rees, and L.E. King, Wolf spider bites. Cutis,

1987. 39(2): p. 113-4. 160. Ribeiro, L.A., et al., Wolf spider bites in Sao

Paulo, Brazil: a clinical and epidemiological study of 515 cases. . 161.

Cruz, J.S., et al., Partial purification and pharmacological

characterization of a neurotoxic fraction isolated from the venom of the

spider Lycosa erythrognatha. Braz-J-Med-Biol-Res, 1994. 27(11): p. 2653-9.

162. Sugiyama, H., I. Ito, and C. Hirono, A new type of glutamate receptor

linked to inositol phospholipid metabolism. Nature, 1987. 325(6104): p.

531-3. 163. Kawai, N., Spider toxin and pertussis toxin differentiate post-

and presynaptic glutamate receptors. Neurosci-Res, 1991. 12(1): p. 3-12.

164. Love, S. and H.-M.A. Cruz, Acute swelling of nodes of Ranvier caused by

venoms which slow inactivation of sodium channels. . 165. Bento, A.C., et

al., Identification of a new vascular smooth muscle contracting polypeptide

in Phoneutria nigriventer spider venom. Biochem-Pharmacol, 1993. 46(6): p.

1092-5. 166. Diniz, C.R., et al., The purification and amino acid sequence

of the lethal neurotoxin Tx1 from the venom of the Brazilian 'armed' spider

Phoneutria nigriventer. FEBS-Lett, 1990. 263(2): p. 251-3. 167. Diniz, M.R.,

et al., Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the

Brazilian "armed" spider Phoneutria nigriventer predicts the synthesis and

processing of a preprotoxin. J-Biol-Chem, 1993. 268(21): p. 15340-2. 168.

Romano, S.-M.A., et al., Rat cortical synaptosomes have more than one

mechanism for Ca2+ entry linked to rapid glutamate release: studies using

the Phoneutria nigriventer toxin PhTX2 and potassium depolarization.

Biochem-J, 1993. 296(Pt 2): p. 313-9. 169. Cordeiro, M.d.-N., et al., The

purification and amino acid sequences of four Tx2 neurotoxins from the venom

of the Brazilian 'armed' spider Phoneutria nigriventer (Keys). FEBS-Lett,

1992. 310(2): p. 153-6. 170. Gomez, R.S., et al., The effect of PhTx3 on the

release of 3H-acetylcholine induced by tityustoxin and potassium in brain

cortical slices and myenteric plexus. Neurosci-Lett, 1995. 196(1-2): p.

131-3. 171. Atkinson, R.K., A comparison of the toxicity of the venoms of

twelve common Australian spider species on rodent vital organ systems.

Comp-Biochem-Physiol-C, 1993. 106(3): p. 639-42. 172. Liang, S.P. and X.

Pan, A lectin-like peptide isolated from the venom of the Chinese bird

spider Selenocosmia huwena. Toxicon, 1995. 33(7): p. 875-82. 173.

Rutherford, A.M. and S.K. Sutherland, Large blister formation after a bite

by the common cupboard spider, genus Steatoda [letter]. Med-J-Aust, 1989.

151(9): p. 542. 174. Warrell, D.A., et al., Neurotoxic envenoming by an

immigrant spider (Steatoda nobilis) in southern England. . 175. Sokolov, I.,

A.N. Chanturiia, and V.K. Lishko, [Channel-forming properties of Steatoda

paykulliana spider venom]. Biofizika, 1984. 29(4): p. 620-3. 176. Mironov,

S.L., et al., Channels produced by spider venoms in bilayer lipid membrane:

mechanisms of ion transport and toxic action. Biochim-Biophys-Acta, 1986.

862(1): p. 185-98. 177. Usmanov, P.B., et al., The channel-forming component

of the Theridiidae spider venom neurotoxins. Gen-Physiol-Biophys, 1985.

4(2): p. 185-93. 178. Vest, D.K., Necrotic arachnidism in the northwest

United States and its probable relationship to Tegenaria agrestis

(Walckenaer) spiders. . 179. Lira, d.-S.-.R.M., et al., Necrotic

arachnidism--Pacific Northwest, 1988-1996 [Retrospective study on

Latrodectus stings in Bahia, Brazil]. MMWR-Morb-Mortal-Wkly-Rep, 1996.

45(21): p. 433-6.